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These effects, together with a prior report showing that a small-molecule ACKR3 agonist CCX771 exhibits anxiolytic-like conduct in mice,2 assist the concept of focusing on ACKR3 as a singular approach to modulate the opioid method, which could open up new therapeutic avenues for opioid-associated Ailments.Distributing this evaluate signifies that y
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Illustrations are quickly compiled from on-line resources to show recent utilization. Browse Extra Opinions expressed while in the examples don't represent People of Merriam-Webster or its editors.Clonidine treats superior hypertension by stimulating α2 receptors while in the brainstem, which decreases peripheral vascular resistance, lowering hyp